Grants

Grants – 2017

Haining Zhu received a Kentucky Lung Cancer Research Program grant entitled “Acetylation of G3BP1 in Lung Cancer”. The amount of funding is $150,000 for the period 07/01/2017 to 06/30/2019. The major goal of the grant is to determine whether G3BP1 acetylation can promote lung cancer progression and whether targeting G3BP1 acetylation provides a novel therapeutic avenue for lung cancer.

Doug Andres received a KSCHIRT grant entitled “G-protein Signaling Reduces Neurodegeneration and Promotes Recovery of Synaptic Strength following Traumatic Brain Injury”. The amount of funding is $300,000 for the period 1/15/17 to 1/14/2020. This project investigates the role of RIT1 G-protein signaling in cellular and functional recovery from brain trauma.

Doug Andres received a multi-PI RO1 with Jon Satin entitled “Monomeric G-proteins and cardioprotection from heart failure”. The amount of funding (total direct plus indirect for 3 years) is approximately 1.6 million dollars. This project investigates the hypothesis that Rad modulates the interdependent relationship between LTCC and β-AR signaling and that Rad deficiency promotes protection against adverse myocardial remodeling.

Robert Dickson received an R56 grant entitled “Characterization of the Sch9 Longevity Pathway in Yeast”. The amount of funding (direct plus indirect) is $382,500, and the grant runs from 09/01/2017 to 08/31/2018.

Sidney Whiteheart renewed his RO1 grant entitled “Molecular Mechanism of Platelet exocytosis”. The amount of funding is $1,881,250, with a grant period from 2017-2021.

Sidney Whiteheart received a new VA Merit award entitled “Targeting Platelet Endocytosis and Exocytosis to Control Thrombosis”. The amount of funding is $928,269 and the grant runs from 2017- 2021.

Sidney Whiteheart received a new RO1 entitled “Platelet endocytosis to innate immunity”. The amount of funding is $2,044,892 and the grant runs from 2017-2021.

Matt Gentry received and Industry Sponsored Project: Valerion Therapeutics, entitled “Defining the action of Fab-amylase as a putative therapeutic for LD”. The amount of funding is $415,000 and the grant runs from 2017-2019.

Konstantin Korotkov, Natalia Korotkov and Jeffrey Rush received a multi-PI COBRE pilot grant entitled “Structural and biochemical perspective of cell-wall biosynthesis in Gram-positive bacteria”. The amount of funding is $50,000 and the grant runs from 2017-2018. The main objective of the grant is to elucidate the mechanism of biogenesis of Group-specific polysaccharides in pathogenic Streptococci.

 Jessica Blackburn received St. Baldrick's Foundation for Pediatric Cancer Research, "Protein tyrosine phosphatases as novel drugs targets in Acute Lymphoblastic Leukemia" $100,000. 6/1/17-5/30/18. This goal of this research is to use zebrafish screens and human leukemia cells to identify FDA-approved

tyrosine phosphatase inhibitors that can be repurposed as targeted anti-cancer therapy in pediatric leukemia.

Jessica Blackburn received NCI Supplement, "Development of fusion oncoprotein models in zebrafish", $163,000. 8/1/17-11/30/18. In response to the Cancer Moonshot Initiative, and in collaboration with St. Jude Children's Research Hospital, this project will use CRISPR technology to develop the first zebrafish models of translocations common to pediatric cancers, with the goal of developing new high- throughput, in vivo drug screening tools.

Jessica Blackburn received NIH New Innovator Award, "Harnessing single cell technology to define self- renewal of normal and malignant stem cells" $2.3 million, 9/1/17-8/30/22. This project utilizes zebrafish leukemia models for single cell sequencing and high resolution in vivo imaging to define the unique biological properties of cancer stem cells, to understand how they respond to chemotherapy in vivo, and to identify new ways to target them therapeutically to prevent leukemia relapse.

Trevor Creamer received a COBRE Pilot Award entitled “Interplay between calcineurin, Rcan1, and tau in Alzheimer’s disease”, $100,000, 5/1/2017-4/30/2018. In this project we are investigating tau undergoing liquid-liquid phase separation, how that is affected by phosphorylation state and dephosphorylation by calcineurin, and the role of Rcan1 in modulating these processes.

Trevor Creamer received a VPR Research Support Grant entitled “Inhibition of calcineurin by Rcan1 and hyperphosphorylation of tau in Alzheimer’s disease”, $10,000, 7/1/2017-6/30/2017. The goal of this project is to determine the extent to which Rcan1 inhibits calcineurin’s dephosphorylation of tau and how that contributes to neurofibrillary tangle formation in Alzheimer’s disease.

Stefan Stamm PI on a R21 entitled “Changing Serotonin Receptor 2C Splice Variants to Combat Spasticity After Spinal Cord”. The award is in the amount of $225,750.

 

Grants

Name of Grant

Sponsor description

External Reference

ANDRES DOUGLASKY Spinal Cord and Head Injury14-1
ANDRES DOUGLASKY Spinal Cord and Head Injury16-1
ANDRES DOUGLASNational Heart Lung and Blood Institute1R56HL131782-01
ANDRES DOUGLASNational Institute of Neurological Disorders & Stroke5R21NS091096-02 REVISED
ANDRES DOUGLASKY Lung Cancer Research FundPO2 415 1400004000 1
BLACKBURN JESSICANational Cancer Institute5R00CA181500-04
BLACKBURN JESSICAAmerican Cancer SocietyIRG 85-001-25
BLACKBURN JESSICAThe V FoundationV2016-001
CREAMER TREVORNational Science FoundationDBI-1358627
CREAMER TREVORNational Science FoundationDBI-1358627
DUTCH REBECCAMedImmune Inc1700056253
DUTCH REBECCANational Institute of Allergy and Infectious Diseases5F30AI114194-03
DUTCH REBECCANational Institute of Allergy and Infectious Diseases5R01AI051517-13
DUTCH REBECCACornell University76300-10618
FONDUFE-MITTENDORF YNational Institute of Environmental Health Sciences5R01ES024478-03
FONDUFE-MITTENDORF YNational Institute of Environmental Health Sciences3R01ES024478-02S1
FONDUFE-MITTENDORF YNational Science FoundationMCB-1517986
FONDUFE-MITTENDORF YNational Science FoundationMCB-1517986
GAL JOZSEFNational Institute of Neurological Disorders & Stroke1R21NS095299-01A1
GALPERIN EMILIANational Institute of General Medical Sciences5R01GM113087-03
GALPERIN EMILIANational Institute of General Medical Sciences3R01GM113087-02S1
GALPERIN EMILIANational Institute of General Medical Sciences3R01GM113087-02S2
GALPERIN EMILIANational Institute of General Medical Sciences3R01GM113087-03
GALPERIN EMILIAAmerican Cancer SocietyRSG-14-172-01-CSM
GALPERIN EMILIAAmerican Heart Association Great Rivers Affiliate15PRE25090207
GENTRY MATTHEWNational Institute of Neurological Disorders & Stroke5P01NS097197-02
WATT DAVIDNational Institute of Neurological Disorders & Stroke5P01NS097197-02
GENTRY MATTHEWNational Institute of Neurological Disorders & Stroke5P01NS097197-02
GENTRY MATTHEWNational Institute of Neurological Disorders & Stroke5P01NS097197-02
GENTRY MATTHEWNational Institute of Neurological Disorders & Stroke5P01NS097197-02
GENTRY MATTHEWNational Institute of Neurological Disorders & Stroke5R01NS070899-08
GENTRY MATTHEWNational Science FoundationMCB-1252345
GENTRY MATTHEWNational Science FoundationMCB-1252345
GENTRY MATTHEWValerion Therapeutics LLCNO ID
GENTRY MATTHEWNational Institute of Neurological Disorders & Stroke5F31NS093892-02
KOROTKOV KONSTANTINNational Institute of Allergy and Infectious Diseases5R01AI119022-03
KOROTKOV KONSTANTINNational Institute of Allergy and Infectious Diseases5R03AI117361-02
KOROTKOVA NATALIANational Institute of Allergy and Infectious Diseases5R21AI113253-02
HERSH LOUISNational Institute of General Medical Sciences5P30GM110787-04
HERSH LOUISNational Institute of General Medical Sciences5P30GM110787-04
WATT DAVIDNational Institute of General Medical Sciences5P30GM110787-04
MENDENHALL MICHAELNational Institute of General Medical Sciences5P30GM110787-04
BACHSTETTER ADAMNational Institute of General Medical Sciences5P30GM110787-04
BLACKBURN JESSICANational Institute of General Medical Sciences5P30GM110787-04
VANDER KOOI CRAIGNational Institute of General Medical Sciences5P30GM110787-04
MURPHY MICHAELNational Institute of Environmental Health Sciences5R21ES024158-02
MURPHY MICHAELBrightFocus FoundationA2014280S
OZCAN SABIREAmerican Heart Association Great Rivers Affiliate14GRNT20380383
RODGERS DAVIDAssociation Francaise Contre Les Myopath18508
RODGERS DAVIDKY Council on Postsecondary EdNO ID
STAMM STEFANNational Institute of Neurological Disorders & Stroke1R21NS09818601-A1
STAMM STEFANNational Institute of Child Health and Human Development5R21HD080035-02
STAMM STEFANFoundation for Prader Willi ResNO ID
WAECHTER CHARLESNational Institute of General Medical Sciences5R01GM102129-04
WATT DAVIDHealth Research Incorporated203-01
WATT DAVIDNational Cancer Institute5R01CA172379-05
WATT DAVIDNational Cancer Institute5R01CA187273-03
WATT DAVIDKY Lung Cancer Research FundPO2 415 1400004000 1
WATT DAVIDUS Army Medical Research      Acquisition ActivityW81XWH-16-1-0635
WHITEHEART SIDNEYAmerican Heart Association Great Rivers Affiliate15PRE25550020
WHITEHEART SIDNEYAmerican Heart Association Great Rivers Affiliate16GRNT27620001
WHITEHEART SIDNEYNational Heart Lung and Blood Institute1R01HL138179-01
WHITEHEART SIDNEYNational Heart Lung and Blood Institute2R01HL056652-18A1
WHITEHEART SIDNEYCase Western ReserveRES511412
ZHU HAININGMuscular Dystrophy AssociationMDA352743