Qingjun Wang

Bio / Education: 

B.S. University of Science & Technology of China
Ph.D. University of Illinois at Urbana-Champaign
Postdoc. The Rockefeller University

Research Description: 

Molecular mechanism of mammalian autophagy and its relevance to human diseases; platelets; neurodegeneration; cancer; aging; proteomics.

Grants: 

Recently Completed Grants:

  • NIH Center of Biomedical Research Excellence (COBRE) in the Molecular Basis of Human Disease, 9/2009-6/2013
  • University Research Postdoctoral Fellowship, 1/2011-12/2012 (Awardee: Deanna H. Morris)
Selected Publications: 

Dr. Qingjun Wang in Google Scholar (http://scholar.google.com/citations?hl=en&user=p8LtLEAAAAAJ)

17. Zhong Y, Morris DH, Jin L, Patel MS, Karunakaran SK, Fu YJ, Matuszak EA, Weiss HL, Chait BT, Wang QJ* (2014) Nrbf2 suppresses autophagy by modulating Atg14L-containing Beclin 1-Vps34 protein complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels. J Biol Chem (In press) (*Corresponding author)

16. Lu J*, He L*, Behrends C, Araki M, Araki K, Wang QJ, Catanzaro JM, Friedman SL, Zong WX, Fiel MI, Li M, Yue Z (2014) NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity. Nat Commun 5:3920.

15. Wang QJ*, Singh A, Li H, Nedbal L, Sherman LA, Govindjee*, Whitmarsh J (2012) Oxygen evolution in the mixotrophically-grown photosystem I deletion mutants of the cyanobacterium Synechocystis sp. PCC 6803. Biochim Biophys Acta – Bioenergetics 1817(5):792-801. (*Co-corresponding authors).

14. Li X, Wang QJ, Pan N, Lee S, Zhao Y, Chait BT, Yue Z (2011). Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common familial mutations of LRRK2 associated with Parkinson’s disease. PLOS One 6(3):e17153.

13. Funderburk SF, Wang QJ, Yue Z (2010). The Beclin 1–VPS34 complex – at the crossroads of autophagy and beyond. Trends Cell Biol 20(6):355-362.

12. Zhong Y, Wang QJ, Yue Z (2009) Atg14L and Rubicon: Yin and yang of Beclin 1-mediated autophagy control. Autophagy 5(6): 890-891.

11. Zhong Y*, Wang QJ*, Li X, Chait BT, Heintz N, Yue Z (2009) Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol 3-kinase complex. Nat Cell Biol 11:468-476 (*Equal contributors).

10. Yue Z, Holstein GR, Chait BT, Wang QJ (2009) Using genetic mouse models to study the biology and pathology of autophagy in the central nervous system. In D Klionsky, ed., Methods Enzymol Vol. 453 “Autophagy: Higher Eukaryotes mammalian and clinical”, p159-180.

9. Westblade LF, Minakhin L, Kuznedelov K, Tackett AJ, Chang EJ, Mooney RA, Vvedenskaya I, Wang QJ, Fenyo D, Rout MP, Landick R, Chait BT, Severinov K, Darst SA (2008) Rapid isolation and identification of bacteriophage T4-encoded modifications of Escherichia coli RNA polymerase: a generic method to study bacteriophage/host interactions. J Proteome Research 7(3):1244-1250.

8. Yue Z, Wang QJ, Komatsu M (2008) Neuronal autophagy: Going the distance to the axon. Autophagy 4(1):94-96.

7. Komatsu M*, Wang QJ*, Holstein GR, Friedrich Jr VL, Iwata JI, Kominami E, Chait BT, Tanaka K, Yue Z (2007) Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A 104(36):14489-14494 (*Equal contributors; direct submission).

6. Fenyo D, Wang QJ, DeGrasse JA, Padovan JC, Cadene M, Chait BT (2007) MALDI sample preparation: the ultra thin layer method. J Visualized Experiments 3:192 (http://www.jove.com/index/Details.stp?ID=192).

5. Wang QJ, Ding Y, Kohtz DS, Mizushima N, Cristea IM, Rout MP, Chait BT, Zhong Y, Heintz N, Yue Z (2006) Induction of autophagy in axonal dystrophy and degeneration. J Neurosci 26(31):8057-8068.

4. Nelson M, Finazzi G, Wang QJ, Middleton-Zarka K, Whitmarsh J, Kallas T (2005) Cytochrome b6 arginine 214 of Synechococcus sp. PCC 7002, a key residue for quinone-reductase site function and turnover of the cytochrome bf complex. J Biol Chem 280(11):10395-10402.

3. Kashino Y, Lauber WM, Carroll JA, Wang QJ, Whitmarsh J, Satoh K, Pakrasi HB (2002) Proteomic analysis of a highly active photosystem II preparation from the cyanobacterium Synechocystis sp. PCC 6803 reveals the presence of novel polypeptides. Biochemistry 41(25):8004-8012.

2. Cho YS, Wang QJ, Krogmann DW, Whitmarsh J (1999) Extinction coefficients and midpoint potentials of cytochrome c6 from the cyanobacteria Arthrospira maxima, Microcystis aeruginosa, and Synechocystis 6803. Biochim Biophys Acta – Bioenergetics 1413(2): 92-97.

1. Guo GC, Guo T, Zheng SB, Wang QJ (1999) Quantum teleportation. Physics 28(9): 120-125.

PubMed Publications: 

  • Yue, Z.;Holstein, G.R.;Chait, B.T.;Wang, Q.J. "Using genetic mouse models to study the biology and pathology of autophagy in the central nervous system." Methods in enzymology 453, (2014): 159-80. [PubMed Link] | [ Full text ]
  • Fenyo, D.;Wang, Q.;DeGrasse, J.A.;Padovan, J.C.;Cadene, M.;Chait, B.T. "MALDI sample preparation: the ultra thin layer method." Journal of visualized experiments : JoVE 3 (2014): 192. [PubMed Link] | [ Full text ]
  • Wang, Q.J.;Singh, A.;Li, H.;Nedbal, L.;Sherman, L.A.;, G.;Whitmarsh, J. "Net light-induced oxygen evolution in photosystem I deletion mutants of the cyanobacterium Synechocystis sp. PCC 6803." Biochimica et biophysica acta 1817, 5 (2012): 792-801. [PubMed Link] | [ Full text ]
  • Li, X.;Wang, Q.J.;Pan, N.;Lee, S.;Zhao, Y.;Chait, B.T.;Yue, Z. "Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease." PloS one 6, 3 (2011): e17153. [PubMed Link] | [ Full text ]
  • Funderburk, S.F.;Wang, Q.J.;Yue, Z. "The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond." Trends in cell biology 20, 6 (2010): 355-62. [PubMed Link] | [ Full text ]
  • Zhong, Y.;Wang, Q.J.;Yue, Z. "Atg14L and Rubicon: yin and yang of Beclin 1-mediated autophagy control." Autophagy 5, 6 (2009): 890-1. [PubMed Link] | [ Full text ]
  • Zhong, Y.;Wang, Q.J.;Li, X.;Yan, Y.;Backer, J.M.;Chait, B.T.;Heintz, N.;Yue, Z. "Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex." Nature cell biology 11, 4 (2009): 468-76. [PubMed Link] | [ Full text ]
  • Westblade, L.F.;Minakhin, L.;Kuznedelov, K.;Tackett, A.J.;Chang, E.J.;Mooney, R.A.;Vvedenskaya, I.;Wang, Q.J.;Fenyö, D.;Rout, M.P.;Landick, R.;Chait, B.T.;Severinov, K.;Darst, S.A. "Rapid isolation and identification of bacteriophage T4-encoded modifications of Escherichia coli RNA polymerase: a generic method to study bacteriophage/host interactions." Journal of proteome research 7, 3 (2008): 1244-50. [PubMed Link] | [ Full text ]
  • Yue, Z.;Wang, Q.J.;Komatsu, M. "Neuronal autophagy: going the distance to the axon." Autophagy 4, 1 (2008): 94-6. [PubMed Link] | [ Full text ]
  • Komatsu, M.;Wang, Q.J.;Holstein, G.R.;Friedrich VL, J.;Iwata, J.;Kominami, E.;Chait, B.T.;Tanaka, K.;Yue, Z. "Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration." Proceedings of the National Academy of Sciences of the United States of America 104, 36 (2007): 14489-94. [PubMed Link] | [ Full text ]
  • Wang, Q.J.;Ding, Y.;Kohtz, D.S.;Mizushima, N.;Cristea, I.M.;Rout, M.P.;Chait, B.T.;Zhong, Y.;Heintz, N.;Yue, Z. "Induction of autophagy in axonal dystrophy and degeneration." The Journal of neuroscience : the official journal of the Society for Neuroscience 26, 31 (2006): 8057-68. [PubMed Link] | [ Full text ]
  • Nelson, M.E.;Finazzi, G.;Wang, Q.J.;Middleton-Zarka, K.A.;Whitmarsh, J.;Kallas, T. "Cytochrome b6 arginine 214 of Synechococcus sp. PCC 7002, a key residue for quinone-reductase site function and turnover of the cytochrome bf complex." The Journal of biological chemistry 280, 11 (2005): 10395-402. [PubMed Link] | [ Full text ]
  • Kashino, Y.;Lauber, W.M.;Carroll, J.A.;Wang, Q.;Whitmarsh, J.;Satoh, K.;Pakrasi, H.B. "Proteomic analysis of a highly active photosystem II preparation from the cyanobacterium Synechocystis sp. PCC 6803 reveals the presence of novel polypeptides." Biochemistry 41, 25 (2002): 8004-12. [PubMed Link] | [ Full text ]
  • Cho, Y.S.;Wang, Q.J.;Krogmann, D.;Whitmarsh, J. "Extinction coefficients and midpoint potentials of cytochrome c(6) from the cyanobacteria Arthrospira maxima, Microcystis aeruginosa, and Synechocystis 6803." Biochimica et biophysica acta 1413, 2 (1999): 92-7. [PubMed Link] | [ Full text ]
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