Zhenyu Li, M.D., Ph.D. | Molecular & Cellular Biochemistry

Zhenyu Li, M.D., Ph.D.

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zhenyuli08@uky.edu

859-257-0528

741 S Limestone St, BBSRB B351, Lexington, KY 40536-0509

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Position(s):

Associate Professor

Affiliation(s):

Internal Medicine

Cardiovascular Research Center

Other Affiliation(s):

CVRC - Core Faculty

Internal Medicine - Cardiology

Bio / Education:

PhD, Soochow University, China
Postdotoral fellow, Pharmacology, University of Illinois at Chicago

Research Description:

The focus of our research is to understand the cellular signaling mechanisms that regulate platelet activation thrombosis, and vascular permeability under normal physiological conditions and during inflammation. Blood platelets and vascular endothelial cells play critical roles in the development of atherosclerosis, thrombotic diseases (such as heart attack and stroke), and inflammatory dieseases. Thus, understanding the mechanisms of platelet and endothelial cell functions at a molecular level will allow us to identify potential targets for therapeutic intervention in cases of cardiovascular diseases and inflammatory diseases. We are currently investigating the role of the cGMP-dependent pathway in regulating platelet activation and thrombosis, and the role of platelets in inflammatory diseases.

PubMed Publications:

Xiang, B.; Zhang, G.; Zhang, Y.; Wu, C.; Joshi, S.; Morris, AJ ; Ware, J.; Smyth, SS ; Whiteheart, SW ; Li, Z. "Calcium Ion Chelation Preserves Platelet Function During Cold Storage." Arteriosclerosis, thrombosis, and vascular biology 41, 1 (2021): 234-249. [PubMed Link] | [ Full text ]
Li, X.; Li, Z.; Zhou, H.; Gaynor, SM ; Liu, Y.; Chen, H.; Sun, R.; Dey, R.; Arnett, DK ; Aslibekyan, S.; Ballantyne, CM ; Bielak, LF ; Blangero, J.; Boerwinkle, E.; Bowden, DW ; Broome, JG ; Conomos, MP ; Correa, A.; Cupples, LA ; Curran, JE ; Freedman, BI ; Guo, X.; Hindy, G ; Irvin, MR ; Kardia, SLR ; Kathiresan, S.; Khan, AT ; Kooperberg, CL ; Laurie, CC ; Liu, XS ; Mahaney, MC ; Manichaikul, AW ; Martin, LW ; Mathias, RA ; McGarvey, ST ; Mitchell, BD ; Montasser, ME ; Moore, JE ; Morrison, AC ; O'Connell, JR ; Palmer, ND ; Pampana, A ; Peralta, JM ; Peyser, PA ; Psaty, BM ; Redline, S.; Rice, KM ; Rich, SS ; Smith, JA ; Tiwari, HK ; Tsai, MY ; Vasan, RS ; Wang, FF ; Weeks, DE ; Weng, Z.; Wilson, JG ; Yanek, LR ; TOPMed), Consortium. N.H.L.B.I.Tran; Working, Group. T.O.P.Med Lip; Neale, BM ; , ; Abecasis, GR ; Rotter, JI ; Willer, CJ ; Peloso, GM ; Natarajan, P ; Lin, X. "Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale." Nature genetics 52, 9 (2020): 969-983. [PubMed Link] | [ Full text ]
Wu, C.; Ye, D.; Mullick, AE ; Li, Z.; Danser, AHJ ; Daugherty, A.; Lu, HS "Effects of Renin-Angiotensin Inhibition on ACE2 (Angiotensin-Converting Enzyme 2) and TMPRSS2 (Transmembrane Protease Serine 2) Expression: Insights Into COVID-19." Hypertension (Dallas, Tex. : 1979) 76, 4 (2020): e29-e30. [PubMed Link] | [ Full text ]
Xiong, G.; Chen, J.; Zhang, G.; Wang, S.; Kawasaki, K ; Zhu, J.; Zhang, Y.; Nagata, K.; Li, Z.; Zhou, BP ; Xu, R. "Hsp47 promotes cancer metastasis by enhancing collagen-dependent cancer cell-platelet interaction." Proceedings of the National Academy of Sciences of the United States of America 117, 7 (2020): 3748-3758. [PubMed Link] | [ Full text ]
Wu, C.; Lu, W.; Zhang, Y.; Zhang, G.; Shi, X.; Hisada, Y ; Grover, SP ; Zhang, X.; Li, L.; Xiang, B.; Shi, J.; Li, XA ; Daugherty, A.; Smyth, SS ; Kirchhofer, D.; Shiroishi, T ; Shao, F.; Mackman, N.; Wei, Y.; Li, Z. "Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis." Immunity 50, 6 (2019): 1401-1411.e4. [PubMed Link] | [ Full text ]
Park, SY ; Yang, JS ; Li, Z.; Deng, P.; Zhu, X.; Young, D.; Ericsson, M ; Andringa, RLH ; Minnaard, AJ ; Zhu, C.; Sun, F.; Moody, DB ; Morris, AJ ; Fan, J.; Hsu, VW "The late stage of COPI vesicle fission requires shorter forms of phosphatidic acid and diacylglycerol." Nature communications 10, 1 (2019): 3409. [PubMed Link] | [ Full text ]
Duan, J.; Li, J.; Zeng, B ; Chen, GL ; Peng, X.; Zhang, Y.; Wang, J.; Clapham, DE ; Li, Z.; Zhang, J. "Structure of the mouse TRPC4 ion channel." Nature communications 9, 1 (2018): 3102. [PubMed Link] | [ Full text ]
Wang, S.; Li, Z.; Xu, R. "Human Cancer and Platelet Interaction, a Potential Therapeutic Target." International journal of molecular sciences 19, 4 (2018): [PubMed Link] | [ Full text ]
Zhang, R.; Zhang, G.; Xiang, B.; Chen, X.; Tang, L.; Shi, S.; Liu, Y.; Ai, X.; Xie, P.; Li, Z. "TRAF3 negatively regulates platelet activation and thrombosis." Scientific reports 7, 1 (2017): 17112. [PubMed Link] | [ Full text ]
Huang, Y.; Joshi, S.; Xiang, B.; Kanaho, Y.; Li, Z.; Bouchard, BA ; Moncman, CL ; Whiteheart, SW "Arf6 controls platelet spreading and clot retraction via integrin αIIbβ3 trafficking." Blood 127, 11 (2016): 1459-67. [PubMed Link] | [ Full text ]
Dong, C.; Li, B.; Li, Z.; Shetty, S.; Fu, J. "Dasatinib-loaded albumin nanoparticles possess diminished endothelial cell barrier disruption and retain potent anti-leukemia cell activity." Oncotarget 7, 31 (2016): 49699-49709. [PubMed Link] | [ Full text ]