Grants

Doug Andres
Doug Andres received a KSCHIRT grant entitled “G-protein Signaling Reduces Neurodegeneration and Promotes Recovery of Synaptic Strength following Traumatic Brain Injury”. The amount of funding is $300,000 for the period 1/15/17 to 1/14/2020. This project investigates the role of RIT1 G-protein signaling in cellular and functional recovery from brain trauma.
Doug Andres received a multi-PI RO1 with Jon Satin entitled “Monomeric G-proteins and cardioprotection from heart failure”. The amount of funding (total direct plus indirect for 3 years) is approximately 1.6 million dollars. This project investigates the hypothesis that Rad modulates the interdependent relationship between LTCC and β-AR signaling and that Rad deficiency promotes protection against adverse myocardial remodeling.
Robert Dickson
Robert Dickson received an R56 grant entitled “Characterization of the Sch9 Longevity Pathway in Yeast”. The amount of funding (direct plus indirect) is $382,500, and the grant runs from 09/01/2017 to 08/31/2018.
Matt Gentry
Matt Gentry received and Industry Sponsored Project: Valerion Therapeutics, entitled “Defining the action of Fab-amylase as a putative therapeutic for LD”. The amount of funding is $415,000 and the grant runs from 2017-2019.
Haining Zhu
Haining Zhu received a Kentucky Lung Cancer Research Program grant entitled “Acetylation of G3BP1 in Lung Cancer”. The amount of funding is $150,000 for the period 07/01/2017 to 06/30/2019. The major goal of the grant is to determine whether G3BP1 acetylation can promote lung cancer progression and whether targeting G3BP1 acetylation provides a novel therapeutic avenue for lung cancer.
Haining Zhu received the KLCR grant.
Jessica Blackburn

Jessica Blackburn received St. Baldrick's Foundation for Pediatric Cancer Research, "Protein tyrosine phosphatases as novel drugs targets in Acute Lymphoblastic Leukemia" $100,000. 6/1/17-5/30/18. This goal of this research is to use zebrafish screens and human leukemia cells to identify FDA-approved

tyrosine phosphatase inhibitors that can be repurposed as targeted anti-cancer therapy in pediatric leukemia.

Jessica Blackburn received NCI Supplement, "Development of fusion oncoprotein models in zebrafish", $163,000. 8/1/17-11/30/18. In response to the Cancer Moonshot Initiative, and in collaboration with St. Jude Children's Research Hospital, this project will use CRISPR technology to develop the first zebrafish models of translocations common to pediatric cancers, with the goal of developing new high- throughput, in vivo drug screening tools.

Jessica Blackburn received NIH New Innovator Award, "Harnessing single cell technology to define self- renewal of normal and malignant stem cells" $2.3 million, 9/1/17-8/30/22. This project utilizes zebrafish leukemia models for single cell sequencing and high resolution in vivo imaging to define the unique biological properties of cancer stem cells, to understand how they respond to chemotherapy in vivo, and to identify new ways to target them therapeutically to prevent leukemia relapse.

Jessica Blackburn recieved the NIH New Innovator Award.

Stefan Stamm
Stefan Stamm PI on a R21 entitled “Changing Serotonin Receptor 2C Splice Variants to Combat Spasticity After Spinal Cord”. The award is in the amount of $225,750.
Stefan Stamm received a grant for Prader Willi Research.
Emilia Galperin
Emilia Galperin received the NIH S10 award. 
Trevor Creamer

Trevor Creamer received a COBRE Pilot Award entitled “Interplay between calcineurin, Rcan1, and tau in Alzheimer’s disease”, $100,000, 5/1/2017-4/30/2018. In this project we are investigating tau undergoing liquid-liquid phase separation, how that is affected by phosphorylation state and dephosphorylation by calcineurin, and the role of Rcan1 in modulating these processes.

Trevor Creamer received a VPR Research Support Grant entitled “Inhibition of calcineurin by Rcan1 and hyperphosphorylation of tau in Alzheimer’s disease”, $10,000, 7/1/2017-6/30/2017. The goal of this project is to determine the extent to which Rcan1 inhibits calcineurin’s dephosphorylation of tau and how that contributes to neurofibrillary tangle formation in Alzheimer’s disease.

Konstantin Koroktov
Konstantin Korotkov, Natalia Korotkov and Jeffrey Rush received a multi-PI COBRE pilot grant entitled “Structural and biochemical perspective of cell-wall biosynthesis in Gram-positive bacteria”. The amount of funding is $50,000 and the grant runs from 2017-2018. The main objective of the grant is to elucidate the mechanism of biogenesis of Group-specific polysaccharides in pathogenic Streptococci.
Sidney Whiteheart 

Sidney Whiteheart renewed his RO1 grant entitled “Molecular Mechanism of Platelet exocytosis”. The amount of funding is $1,881,250, with a grant period from 2017-2021.

Sidney Whiteheart received a new VA Merit award entitled “Targeting Platelet Endocytosis and Exocytosis to Control Thrombosis”. The amount of funding is $928,269 and the grant runs from 2017- 2021.

Sidney Whiteheart received a new RO1 entitled “Platelet endocytosis to innate immunity”. The amount of funding is $2,044,892 and the grant runs from 2017-2021.

Sidney Whiteheart received the COBRE pilot award.

 

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