Our full departmental research profile can be found on Scholars@UK.
A Novel Protozoa Parasite-Derived Protein Adjuvant Is Effective in Immunization with Cancer Cells to Activate the Cancer-Specific Protective Immunity and Inhibit the Cancer Growth in a Murine Model of Colorectal Cancer
Mani, R., Martin, C. G., Balu, K. E., Wang, Q., Rychahou, P., Izumi, T., Evers, B. M. & Suzuki, Y., Jan 2024, In: Cells. 13, 2, 111.Research output: Contribution to journal › Article › peer-review
EcoHIV-Infected Mice Show No Signs of Platelet Activation
Alfar, H. R., Nthenge-Ngumbau, D. N., Saatman, K. E. & Whiteheart, S. W., Jan 2024, In: Viruses. 16, 1, 55.Research output: Contribution to journal › Article › peer-review
Influence of FTDP-17 mutants on circular tau RNAs
Margvelani, G., Welden, J. R., Maquera, A. A., Van Eyk, J. E., Murray, C., Miranda Sardon, S. C. & Stamm, S., Apr 2024, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1870, 4, 167036.Research output: Contribution to journal › Article › peer-review
The amyloid-β peptide: Guilty as charged?
Murphy, M. P., Buzinova, V. A. & Johnson, C. E., Feb 2024, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1870, 2, 166945.Research output: Contribution to journal › Article › peer-review
ABL1/2 and DDR1 Drive MEKi Resistance in NRAS-Mutant Melanomas by Stabilizing RAF/MYC/ETS1 and Promoting RAF Homodimerization
Lyon, A., Tripathi, R., Meeks, C., He, D., Wu, Y., Liu, J., Wang, C., Chen, J., Zhu, H., Mukherjee, S., Ganguly, S. & Plattner, R., Feb 2023, In: Cancers. 15, 3, 954.Research output: Contribution to journal › Article › peer-review
A blunted TH17 cytokine signature in women with mild cognitive impairment: insights from inflammatory profiling of a community-based cohort of older adults
Bachstetter, A. D., Lutshumba, J., Winford, E., Abner, E. L., Martin, B. J., Harp, J. P., Van Eldik, L. J., Schmitt, F. A., Wilcock, D. M., Stowe, A. M., Jicha, G. A. & Nikolajczyk, B. S., 2023, In: Brain Communications. 5, 5, fcad259.Research output: Contribution to journal › Article › peer-review
A Case for Accelerating Standards to Achieve the FAIR Principles of Environmental Health Research Experimental Data
Nault, R., Cave, M. C., Ludewig, G., Moseley, H. N. B., Pennell, K. G. & Zacharewski, T., Jun 2023, In: Environmental Health Perspectives. 131, 6, 065001.Research output: Contribution to journal › Article › peer-review
Activated protein C, protein S, and tissue factor pathway inhibitor cooperate to inhibit thrombin activation
Li, X., Song, X., Mahmood, D. F. D., Sim, M. M. S., Bidarian, S. J. & Wood, J. P., Oct 2023, In: Thrombosis Research. 230, p. 84-93 10 p.Research output: Contribution to journal › Article › peer-review
Alzheimer’s disease pathogenetic progression is associated with changes in regulated retained introns and editing of circular RNAs
Arizaca Maquera, K. A., Welden, J. R., Margvelani, G., Miranda Sardón, S. C., Hart, S., Robil, N., Hernandez, A. G., de la Grange, P., Nelson, P. T. & Stamm, S., 2023, In: Frontiers in Molecular Neuroscience. 16, 1141079.Research output: Contribution to journal › Article › peer-review
A monoadduct generating Ru(ii) complex induces ribosome biogenesis stress and is a molecular mimic of phenanthriplatin
Mitchell, R. J., Kriger, S. M., Fenton, A. D., Havrylyuk, D., Pandeya, A., Sun, Y., Smith, T., DeRouchey, J. E., Unrine, J. M., Oza, V., Blackburn, J. S., Wei, Y., Heidary, D. K. & Glazer, E. C., May 10 2023, In: RSC Chemical Biology. 4, 5, p. 344-353 10 p.Research output: Contribution to journal › Article › peer-review
A monoadduct generating Ru(ii) complex induces ribosome biogenesis stress and is a molecular mimic of phenanthriplatin
Mitchell, R. J., Kriger, S. M., Fenton, A. D., Havrylyuk, D., Pandeya, A., Sun, Y., Smith, T., DeRouchey, J. E., Unrine, J. M., Oza, V., Blackburn, J. S., Wei, Y., Heidary, D. K. & Glazer, E. C., Feb 27 2023, In: RSC Chemical Biology. 4, 5, p. 344-353 10 p.Research output: Contribution to journal › Article › peer-review
A proposed FAIR approach for disseminating geospatial information system maps
Thompson, P. T., Ojha, S., Powell, C. D., Pennell, K. G. & Moseley, H. N. B., Dec 2023, In: Scientific data. 10, 1, 389.Research output: Contribution to journal › Article › peer-review
Art2 mediates selective endocytosis of methionine transporters during adaptation to sphingolipid depletion
Hepowit, N. L., Moon, B., Ebert, A. C., Dickson, R. C. & MacGurn, J. A., Jul 2023, In: Journal of Cell Science. 136, 14, jcs260675.Research output: Contribution to journal › Article › peer-review
Bilirubin Nanoparticle Treatment in Obese Mice Inhibits Hepatic Ceramide Production and Remodels Liver Fat Content
Kipp, Z. A., Martinez, G. J., Bates, E. A., Maharramov, A. B., Flight, R. M., Moseley, H. N. B., Morris, A. J., Stec, D. E. & Hinds, T. D., Feb 2023, In: Metabolites. 13, 2, 215.Research output: Contribution to journal › Article › peer-review
Bridging the Biomarker Chasm With Interprofessional Molecular Tumor Boards
Kolesar, J. M., Arnold, S. M., Ueland, F. R. & Evers, B. M., Aug 1 2023, In: JCO Oncology Practice. 19, 8, p. 677-678 2 p.Research output: Contribution to journal › Letter › peer-review
Cannabidiol’s Multifactorial Mechanisms Has Therapeutic Potential for Aneurysmal Subarachnoid Hemorrhage: a Review
Henry, N., Fraser, J. F., Chappell, J., Langley, T. & Roberts, J. M., Jun 2023, In: Translational Stroke Research. 14, 3, p. 283-296 14 p.Research output: Contribution to journal › Review article › peer-review
Cervical spinal cord injury leads to injury and altered metabolism in the lungs
Huffman, E. E., Dong, B. E., Clarke, H. A., Young, L. E. A., Gentry, M. S., Allison, D. B., Sun, R. C., Waters, C. M. & Alilain, W. J., 2023, In: Brain Communications. 5, 2, fcad091.Research output: Contribution to journal › Article › peer-review
Chalcone Derivative CX258 Suppresses Colorectal Cancer via Inhibiting the TOP2A/Wnt/β-Catenin Signaling
Chen, X., Lv, X., Gao, L., Liu, J., Wang, W., Guo, L., Frasinyuk, M. S., Zhang, W., Watt, D., Liu, C. & Liu, X., Apr 2023, In: Cells. 12, 7, 1066.Research output: Contribution to journal › Article › peer-review
Computational Investigation of a Series of Small Molecules as Potential Compounds for Lysyl Hydroxylase-2 (LH2) Inhibition
Maghsoud, Y., Vázquez-Montelongo, E. A., Yang, X., Liu, C., Jing, Z., Lee, J., Harger, M., Smith, A. K., Espinoza, M., Guo, H. F., Kurie, J. M., Dalby, K. N., Ren, P. & Cisneros, G. A., Feb 13 2023, In: Journal of Chemical Information and Modeling. 63, 3, p. 986-1001 16 p.Research output: Contribution to journal › Article › peer-review
Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
Matharu, S. S., Nordmann, C. S., Ottman, K. R., Akkem, R., Palumbo, D., Cruz, D. R. D., Campbell, K., Sievert, G., Sturgill, J., Porterfield, J. Z., Joshi, S., Alfar, H. R., Peng, C., Pokrovskaya, I. D., Kamykowski, J. A., Wood, J. P., Garvy, B., Aronova, M. A., Whiteheart, S. W., Leapman, R. D., & 1 others , 2023, In: Platelets. 34, 1, 2264978.Research output: Contribution to journal › Article › peer-review
Development and characterization of nanobodies that specifically target the oncogenic Phosphatase of Regenerating Liver-3 (PRL-3) and impact its interaction with a known binding partner, CNNM3
Smith, C. N., Kihn, K., Williamson, Z. A., Chow, K. M., Hersh, L. B., Korotkov, K. V., Deredge, D. & Blackburn, J. S., May 2023, In: PLoS ONE. 18, 5 May, e0285964.Research output: Contribution to journal › Article › peer-review
Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection
Jun 13 2023, In: JAMA - Journal of the American Medical Association. 329, 22, p. 1934-1946 13 p.Research output: Contribution to journal › Article › peer-review
Ferric Chloride-Induced Arterial Thrombosis and Sample Collection for 3D Electron Microscopy Analysis
Joshi, S., Smith, A. N., Prakhya, K. S., Alfar, H. R., Lykins, J., Zhang, M., Pokrovskaya, I., Aronova, M., Leapman, R. D., Storrie, B. & Whiteheart, S. W., Mar 2023, In: Journal of Visualized Experiments. 2023, 193, e64985.Research output: Contribution to journal › Article › peer-review
Genomic screening methodology not requiring barcoding: Single nucleotide polymorphism-based, mixed-cell screening (SMICS)
Zhang, Z., Chen, X., Zhang, W., Liu, J., Xie, Y., Zhang, S., Stromberg, A. J., Watt, D. S., Liu, X., Wang, C. & Liu, C., Sep 2023, In: Genomics. 115, 5, 110666.Research output: Contribution to journal › Article › peer-review
Glycolytic Regulation of Intestinal Stem Cell Self-Renewal and Differentiation
Li, C., Zhou, Y., Wei, R., Napier, D. L., Sengoku, T., Alstott, M. C., Liu, J., Wang, C., Zaytseva, Y. Y., Weiss, H. L., Wang, Q. & Evers, B. M., Jan 2023, In: CMGH. 15, 4, p. 931-947 17 p.Research output: Contribution to journal › Article › peer-review
Heterogeneity of the group B streptococcal type VII secretion system and influence on colonization of the female genital tract
Spencer, B. L., Job, A. M., Robertson, C. M., Hameed, Z. A., Serchejian, C., Wiafe-Kwakye, C. S., Mendonça, J. C., Apolonio, M. A., Nagao, P. E., Neely, M. N., Korotkova, N., Korotkov, K. V., Patras, K. A. & Doran, K. S., Aug 2023, In: Molecular Microbiology. 120, 2, p. 258-275 18 p.Research output: Contribution to journal › Article › peer-review
Identifying and sharing per-and polyfluoroalkyl substances hot-spot areas and exposures in drinking water
Ojha, S., Thompson, P. T., Powell, C. D., Moseley, H. N. B. & Pennell, K. G., Dec 2023, In: Scientific data. 10, 1, 388.Research output: Contribution to journal › Article › peer-review
Imaging analysis reveals budding of filamentous human metapneumovirus virions and direct transfer of inclusion bodies through intercellular extensions
Najjar, F. E., Castillo, S. R., Moncman, C. L., Wu, C. Y., Isla, E., Velez Ortega, A. C., Frolenkov, G. I., Cifuentes-Munoz, N. & Dutch, R. E., Oct 2023, In: mBio. 14, 5Research output: Contribution to journal › Article › peer-review
Impact of the Affordable Care Act on Providing Equitable Healthcare Access for IBD in the Kentucky Appalachian Region
Castle, J. T., Levy, B. E., Mangino, A. A., McDonald, H. G., McAtee, E. E., Patel, J. A., Evers, B. M. & Bhakta, A. S., Sep 1 2023, In: Diseases of the Colon and Rectum. 66, 9, p. 1273-1281 9 p.Research output: Contribution to journal › Article › peer-review
Impaired activity and membrane association of most calpain-5 mutants causal for neovascular inflammatory vitreoretinopathy
Geddes, J. W., Bondada, V., Croall, D. E., Rodgers, D. W. & Gal, J., Aug 2023, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1869, 6, 166747.Research output: Contribution to journal › Article › peer-review
Inhibition of mitochondrial fission activates glycogen synthesis to support cell survival in colon cancer
Hasani, S., Young, L. E. A., Van Nort, W., Banerjee, M., Rivas, D. R., Kim, J., Xiong, X., Sun, R. C., Gentry, M. S., Sesaki, H. & Gao, T., Oct 2023, In: Cell Death and Disease. 14, 10, 664.Research output: Contribution to journal › Article › peer-review
In memory of Dr. Susan S. Smyth, MD/Ph.D
Whiteheart, S. W., Dec 1 2023, In: Platelets. 34, 1, p. 2183050 1 p.Research output: Contribution to journal › Article › peer-review
In situ microwave fixation provides an instantaneous snapshot of the brain metabolome
Juras, J. A., Webb, M. B., Young, L. E. A., Markussen, K. H., Hawkinson, T. R., Buoncristiani, M. D., Bolton, K. E., Coburn, P. T., Williams, M. I., Sun, L. P. Y., Sanders, W. C., Bruntz, R. C., Conroy, L. R., Wang, C., Gentry, M. S., Smith, B. N. & Sun, R. C., Apr 24 2023, In: Cell Reports Methods. 3, 4, 100455.Research output: Contribution to journal › Article › peer-review
kegg_pull: a software package for the RESTful access and pulling from the Kyoto Encyclopedia of Gene and Genomes
Huckvale, E. & Moseley, H. N. B., Dec 2023, In: BMC Bioinformatics. 24, 1, 78.Research output: Contribution to journal › Article › peer-review
Liver transplantation for biliary cysts: perioperative and long-term outcomes
Orozco, G., Shah, M. B., Gupta, M., Marti, F., Mei, X., Ancheta, A., Desai, S., Cavnar, M., Evers, B. M., Zwischenberger, J. & Gedaly, R., Aug 2023, In: HPB. 25, 8, p. 954-961 8 p.Research output: Contribution to journal › Article › peer-review
MESSES: Software for Transforming Messy Research Datasets into Clean Submissions to Metabolomics Workbench for Public Sharing
Thompson, P. T. & Moseley, H. N. B., Jul 2023, In: Metabolites. 13, 7, 842.Research output: Contribution to journal › Article › peer-review
NF-<bold>κ</bold>B represses retinoic acid receptor–mediated GPRC5A transactivation in lung epithelial cells to promote neoplasia
Song, H., Ye, X., Liao, Y., Zhang, S., Xu, D., Zhong, S., Jing, B., Wang, T., Sun, B., Xu, J., Guo, W., Li, K., Hu, M., Kuang, Y., Ling, J., Zhang, T., Wu, Y., Du, J., Yao, F., Chin, Y. E., & 3 others , Jan 10 2023, In: JCI insight. 8, 1, e153976.Research output: Contribution to journal › Article › peer-review
Noncovalent interactions that tune the reactivities of the flavins in bifurcating electron transferring flavoprotein
González-Viegas, M., Kar, R. K., Miller, A. F. & Mroginski, M. A., Jun 2023, In: Journal of Biological Chemistry. 299, 6, 104762.Research output: Contribution to journal › Article › peer-review
Novel strategies in antithrombotic therapy: targeting thrombosis while preserving hemostasis
Sim, M. M. S., Shiferawe, S. & Wood, J. P., 2023, In: Frontiers in Cardiovascular Medicine. 10, 1272971.Research output: Contribution to journal › Review article › peer-review
Opioid Use After Colorectal Resection: Identifying Preoperative Risk Factors for Postoperative Use
Levy, B. E., Castle, J. T., Ebbitt, L. M., Kennon, C., McAtee, E., Davenport, D. L., Evers, B. M. & Bhakta, A., Mar 2023, In: Journal of Surgical Research. 283, p. 296-304 9 p.Research output: Contribution to journal › Article › peer-review
Paramyxoviruses: Pathogenesis, Vaccines, Antivirals, and Prototypes for Pandemic Preparedness
Paul Duprex, W. & Dutch, R. E., Oct 15 2023, In: Journal of Infectious Diseases. 228, p. S390-S397Research output: Contribution to journal › Article › peer-review
PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence
Xiao, M., Wu, C. H., Meek, G., Kelly, B., Castillo, D. B., Young, L. E. A., Martire, S., Dhungel, S., McCauley, E., Saha, P., Dube, A. L., Gentry, M. S., Banaszynski, L. A., Sun, R. C. & Kikani, C. K., Apr 2023, In: eLife. 12, e81717.Research output: Contribution to journal › Article › peer-review
Phosphatase and Pseudo-Phosphatase Functions of Phosphatase of Regenerating Liver 3 (PRL-3) Are Insensitive to Divalent Metals In Vitro
Jolly, J. T., Cheatham, T. C. & Blackburn, J. S., Aug 22 2023, In: ACS Omega. 8, 33, p. 30578-30589 12 p.Research output: Contribution to journal › Article › peer-review
Phosphatidic acid binding to Patched contributes to the inhibition of Smoothened and Hedgehog signaling in Drosophila wing development
Zhang, J., Liu, Y., Wang, C., Vander Kooi, C. W. & Jia, J., Oct 17 2023, In: Science Signaling. 16, 807, eadd6834.Research output: Contribution to journal › Article › peer-review
Plasma tissue-type plasminogen activator is associated with lipoprotein(a) and clinical outcomes in hospitalized patients with COVID-19
Zhang, Z., Dai, W., Zhu, W., Rodriguez, M., Lund, H., Xia, Y., Chen, Y., Rau, M., Schneider, E. A., Graham, M. B., Jobe, S., Wang, D., Cui, W., Wen, R., Whiteheart, S. W., Wood, J. P., Silverstein, R., Berger, J. S., Kreuziger, L. B., Barrett, T. J., & 1 others , Aug 2023, In: Research and Practice in Thrombosis and Haemostasis. 7, 6, 102164.Research output: Contribution to journal › Article › peer-review
Platelet glycogenolysis is important for energy production and function
Prakhya, K. S., Vekaria, H., Coenen, D. M., Omali, L., Lykins, J., Joshi, S., Alfar, H. R., Wang, Q. J., Sullivan, P. & Whiteheart, S. W., 2023, In: Platelets. 34, 1, 2222184.Research output: Contribution to journal › Article › peer-review
Platelet-localized ST6Gal1 does not impact IgG sialylation
Glendenning, L. M., Zhou, J. Y., Kukan, E. N., Gao, C., Cummings, R. D., Joshi, S., Whiteheart, S. W. & Cobb, B. A., Nov 1 2023, In: Glycobiology. 33, 11, p. 943-953 11 p.Research output: Contribution to journal › Review article › peer-review
Polycomb deficiency drives a FOXP2-high aggressive state targetable by epigenetic inhibitors
Chen, F., Byrd, A. L., Liu, J., Flight, R. M., DuCote, T. J., Naughton, K. J., Song, X., Edgin, A. R., Lukyanchuk, A., Dixon, D. T., Gosser, C. M., Esoe, D. P., Jayswal, R. D., Orkin, S. H., Moseley, H. N. B., Wang, C. & Brainson, C. F., Dec 2023, In: Nature Communications. 14, 1, 336.Research output: Contribution to journal › Article › peer-review
Predictors and outcomes of acute pulmonary embolism in COVID-19; insights from US National COVID cohort collaborative
Gul, M. H., Htun, Z. M., de Jesus Perez, V., Suleman, M., Arshad, S., Imran, M., Vyasabattu, M., Wood, J. P., Anstead, M. & Morris, P. E., Dec 2023, In: Respiratory Research. 24, 1, 59.Research output: Contribution to journal › Article › peer-review
Protocol for optimizing production and quality control of infective EcoHIV virions
Alfar, H. R., Pariser, D. N., Chanzu, H., Joshi, S., Coenen, D. M., Lykins, J., Prakhya, K. S., Potash, M. J., Chao, W., Kelschenbach, J., Volsky, D. J., Metcalf-Pate, K. & Whiteheart, S. W., Sep 15 2023, In: STAR Protocols. 4, 3, 102368.Research output: Contribution to journal › Article › peer-review