rcsu222

Ramon C Sun

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Education
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8595622298

741 S. Limestone Street, BBSRB B179, Lexington, KY 40536

Ramon completed his undergraduate degree from the University of Auckland; Ph.D. from Australian National University, and post-doctoral fellowship at Stanford University. He is now a tenure-track Faculty at the Department of Neuroscience.

Position(s):

Assistant Professor of Neuroscience

Affiliation(s):

Neuroscience

Spinal Cord and Brain Injury Research Center

Other Affiliation(s):

SCOBIRC - Faculty Associates

Bio / Education:

2018-2019 University of Kentucky, Lexington, KY
Research Assistant Professor, Department of Biochemistry, College of Medicine
2016-2018 University of Kentucky, Lexington, KY
T32 Postdoctoral Fellow of Metabolomics, Department of Toxicology, College of Medicine
2011-2015 Stanford University, Palo Alto, CA
Postdoctoral Scholar, Department of Radiation Oncology, School of Medicine
2010 The Australian National University, Canberra, Australia
Ph.D. Cancer Biology and Biochemistry
2006 University of Auckland, Auckland, New Zealand
Bachelor of Biotechnology, First Class Honors.

Research Description:

My scientific philosophy is that I want to find true, clinically relevant and widely applicable mechanisms of disease. Therefore, my lab employs multiple models, from cell-free to animal models, multiple techniques, including metabolomics, histology, genetic manipulations, and pharmacological approaches to tackle complex biological questions. The current research focuses on how N-link glycans affect metabolism and disease progression in Ewing's Sarcoma and late-onset Alzheimer's disease.

Grants:

St Baldricks Career Development Award
Rally Foundation Research Grant
NIH/NIA: 1R01AG0666653-01

Selected Publications:

1. Sun, R. C.*, Dukhande, V. V., Zhou, Z., Young, L. E., Emanuelle, S., Brainson, C. F., and Gentry, M. S. (2019) Nuclear glycogenolysis modulates histone acetylation in human non-small cell lung cancers. Cell Metabolism 30, 903-916. e907 *Co-corresponding Author.

2. Andres, D. A., Young, L. E. A., Veeranki, S., Hawkinson, T. R., Levitan, B. M., He, D., Wang, C., Satin, J., and Sun, R. C. (2020) Improved workflow for mass spectrometry-based metabolomics analysis of the heart. Journal of Biological Chemistry *Corresponding Author.

3. Sun, R. C., Fan, T. W.-M., Deng, P., Higashi, R. M., Lane, A. N., Le, A.-T., Scott, T. L., Sun, Q., Warmoes, M. O., and Yang, Y. (2017) Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing. Nature Communications 8, 1646

4. Sun, R. C., and Denko, N. C. (2014) Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth. Cell Metabolism 19, 285-292

5. Sun, R. C., Board, P. G., and Blackburn, A. C. (2011) Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells. Molecular Cancer 10, 142

6. Brewer, M. K., Uittenbogaard, A., Austin, G. L., Segvich, D. M., DePaoli-Roach, A., Roach, P. J., McCarthy, J. J., Simmons, Z. R., Brandon, J. A., Zhou, Z., Zeller, J., Young, L. E. A., Sun, R. C., Pauly, J. R., Aziz, N. M., Hodges, B. L., McKnight, T. R., Armstrong, D. D., and Gentry, M. S. (2019) Targeting Pathogenic Lafora Bodies in Lafora Disease Using an Antibody-Enzyme Fusion. Cell Metabolism 30, 689-705.e686

PubMed Publications:

Hawkinson, TR ; Sun, RC "Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of Glycogen In Situ." Methods in molecular biology (Clifton, N.J.) 2437, (2022): 215-228. [PubMed Link] | [ Full text ]
Farmer, BC ; Williams, HC ; Devanney, NA ; Piron, MA ; Nation, GK ; Carter, DJ ; Walsh, AE ; Khanal, R ; Young, LEA ; Kluemper, JC ; Hernández, G.; Allenger, EJ ; Mooney, R ; Golden, LR ; Smith, CT ; Brandon, JA ; Gupta, VA ; Kern, PA ; Gentry, MS ; Morganti, JM ; Sun, RC ; Johnson, LA "APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis." Molecular neurodegeneration 16, 1 (2021): 62. [PubMed Link] | [ Full text ]
Duran, J ; Hervera, A ; Markussen, KH ; Varea, O ; López-Soldado, I ; Sun, RC ; Del Río, JA ; Gentry, MS ; Guinovart, JJ "Astrocytic glycogen accumulation drives the pathophysiology of neurodegeneration in Lafora disease." Brain : a journal of neurology 144, 8 (2021): 2349-2360. [PubMed Link] | [ Full text ]
Andersen, JV ; Skotte, NH ; Christensen, SK ; Polli, FS ; Shabani, M ; Markussen, KH ; Haukedal, H ; Westi, EW ; Diaz-delCastillo, M ; Sun, RC ; Kohlmeier, KA ; Schousboe, A.; Gentry, MS ; Tanila, H ; Freude, KK ; Aldana, BI ; Mann, M ; Waagepetersen, HS "Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease." Cell death & disease 12, 11 (2021): 954. [PubMed Link] | [ Full text ]
Conroy, LR ; Stanback, AE ; Young, LEA ; Clarke, HA ; Austin, GL ; Liu, J.; Allison, DB ; Sun, RC "In Situ Analysis of N-Linked Glycans as Potential Biomarkers of Clinical Course in Human Prostate Cancer." Molecular cancer research : MCR 19, 10 (2021): 1727-1738. [PubMed Link] | [ Full text ]
Noe, JT ; Rendon, BE ; Geller, AE ; Conroy, LR ; Morrissey, SM ; Young, LEA ; Bruntz, RC ; Kim, EJ ; Wise-Mitchell, A ; Rizzo, Barbosa de Souza; Relich, ER ; Baby, BV ; Johnson, LA ; Affronti, HC ; McMasters, KM ; Clem, BF ; Gentry, MS ; Yan, J.; Wellen, KE ; Sun, RC ; Mitchell, RA "Lactate supports a metabolic-epigenetic link in macrophage polarization." Science advances 7, 46 (2021): eabi8602. [PubMed Link] | [ Full text ]
Hepowit, NL ; Macedo, JKA ; Young, LEA ; Liu, K.; Sun, RC ; MacGurn, JA ; Dickson, RC "Enhancing lifespan of budding yeast by pharmacological lowering of amino acid pools." Aging 13, 6 (2021): 7846-7871. [PubMed Link] | [ Full text ]
Stanback, AE ; Conroy, LR ; Young, LEA ; Hawkinson, TR ; Markussen, KH ; Clarke, HA ; Allison, DB ; Sun, RC "Regional N-glycan and lipid analysis from tissues using MALDI-mass spectrometry imaging." STAR protocols 2, 1 (2021): 100304. [PubMed Link] | [ Full text ]
Kinslow, CJ ; Chaudhary, KR ; Upadhyayula, PS ; Wang, TJC ; Sun, RC ; Cheng, SK "Purine synthesis as a target for radiation resistance in molecular glioblastoma." Journal of the neurological sciences 425, (2021): 117439. [PubMed Link] | [ Full text ]
Sun, RC ; Young, LEA ; Bruntz, RC ; Markussen, KH ; Zhou, Z.; Conroy, LR ; Hawkinson, TR ; Clarke, HA ; Stanback, AE ; Macedo, JKA ; Emanuelle, S.; Brewer, MK ; Rondon, AL ; Mestas, A ; Sanders, WC ; Mahalingan, KK ; Tang, B.; Chikwana, VM ; Segvich, DM ; Contreras, CJ ; Allenger, EJ ; Brainson, CF ; Johnson, LA ; Taylor, RE ; Armstrong, DD ; Shaffer, R ; Waechter, CJ ; Vander Kooi, CW ; DePaoli-Roach, AA ; Roach, PJ ; Hurley, TD ; Drake, RR ; Gentry, MS "Brain glycogen serves as a critical glucosamine cache required for protein glycosylation." Cell metabolism 33, 7 (2021): 1404-1417.e9. [PubMed Link] | [ Full text ]
Hawkinson, TR ; Clarke, HA ; Young, LEA ; Conroy, LR ; Markussen, KH ; Kerch, KM ; Johnson, LA ; Nelson, PT ; Wang, C.; Allison, DB ; Gentry, MS ; Sun, RC "In situ spatial glycomic imaging of mouse and human Alzheimer's disease brains." Alzheimer's & dementia : the journal of the Alzheimer's Association (2021): [PubMed Link] | [ Full text ]
Conroy, LR ; Hawkinson, TR ; Young, LEA ; Gentry, MS ; Sun, RC "Emerging roles of N-linked glycosylation in brain physiology and disorders." Trends in endocrinology and metabolism: TEM 32, 12 (2021): 980-993. [PubMed Link] | [ Full text ]
Myint, ZW ; Sun, RC ; Hensley, PJ ; James, AC ; Wang, P.; Strup, SE ; McDonald, RJ ; Yan, D.; St Clair, WH ; Allison, DB "Evaluation of Glutaminase Expression in Prostate Adenocarcinoma and Correlation with Clinicopathologic Parameters." Cancers 13, 9 (2021): [PubMed Link] | [ Full text ]
Kinslow, CJ ; Sun, RC ; Chaudhary, KR ; Cheng, SK ""Serine and One-Carbon Metabolism in Breast Cancer Metastasis"-Letter." Molecular cancer research : MCR 18, 11 (2020): 1755. [PubMed Link] | [ Full text ]
Williams, HC ; Farmer, BC ; Piron, MA ; Walsh, AE ; Bruntz, RC ; Gentry, MS ; Sun, RC ; Johnson, LA "APOE alters glucose flux through central carbon pathways in astrocytes." Neurobiology of disease 136, (2020): 104742. [PubMed Link] | [ Full text ]
Donohue, KJ ; Gentry, MS ; Sun, RC "The E3 ligase malin plays a pivotal role in promoting nuclear glycogenolysis and histone acetylation." Annals of translational medicine 8, 5 (2020): 254. [PubMed Link] | [ Full text ]
Zhou, Z.; Kinslow, CJ ; Wang, P.; Huang, B.; Cheng, SK ; Deutsch, I ; Gentry, MS ; Sun, RC "Clear Cell Adenocarcinoma of the Urinary Bladder Is a Glycogen-Rich Tumor with Poorer Prognosis." Journal of clinical medicine 9, 1 (2020): [PubMed Link] | [ Full text ]
Conroy, LR ; Dougherty, S.; Kruer, T ; Metcalf, S ; Lorkiewicz, P.; He, L.; Yin, X.; Zhang, X.; Arumugam, S.; Young, LEA ; Sun, RC ; Clem, BF "Loss of Rb1 Enhances Glycolytic Metabolism in Kras-Driven Lung Tumors In Vivo." Cancers 12, 1 (2020): [PubMed Link] | [ Full text ]
Andres, DA ; Young, LEA ; Veeranki, S.; Hawkinson, TR ; Levitan, BM ; He, D.; Wang, C.; Satin, J.; Sun, RC "Improved workflow for mass spectrometry-based metabolomics analysis of the heart." The Journal of biological chemistry 295, 9 (2020): 2676-2686. [PubMed Link] | [ Full text ]
Young, LEA ; Brizzee, CO ; Macedo, JKA ; Murphy, RD ; Contreras, CJ ; DePaoli-Roach, AA ; Roach, PJ ; Gentry, MS ; Sun, RC "Accurate and sensitive quantitation of glucose and glucose phosphates derived from storage carbohydrates by mass spectrometry." Carbohydrate polymers 230, (2020): 115651. [PubMed Link] | [ Full text ]
Williams, HC ; Piron, MA ; Nation, GK ; Walsh, AE ; Young, LEA ; Sun, RC ; Johnson, LA "Oral Gavage Delivery of Stable Isotope Tracer for In Vivo Metabolomics." Metabolites 10, 12 (2020): [PubMed Link] | [ Full text ]
Andres, DA ; Young, LEA ; Gentry, MS ; Sun, RC "Spatial profiling of gangliosides in mouse brain by mass spectrometry imaging." Journal of lipid research 61, 12 (2020): 1537. [PubMed Link] | [ Full text ]
Andres, DA ; Young, LEA ; Gentry, MS ; Sun, RC "Spatial profiling of gangliosides in mouse brain by mass spectrometry imaging." Journal of lipid research 61, 12 (2020): 1537. [PubMed Link] | [ Full text ]
Andres, DA ; Young, LEA ; Gentry, MS ; Sun, RC "Spatial profiling of gangliosides in mouse brain by mass spectrometry imaging." Journal of lipid research 61, 12 (2020): 1537. [PubMed Link] | [ Full text ]
Brewer, MK ; Uittenbogaard, A.; Austin, GL ; Segvich, DM ; DePaoli-Roach, A ; Roach, PJ ; McCarthy, JJ ; Simmons, ZR ; Brandon, JA ; Zhou, Z.; Zeller, J ; Young, LEA ; Sun, RC ; Pauly, JR ; Aziz, NM ; Hodges, BL ; McKnight, TR ; Armstrong, DD ; Gentry, MS "Targeting Pathogenic Lafora Bodies in Lafora Disease Using an Antibody-Enzyme Fusion." Cell metabolism 30, 4 (2019): 689-705.e6. [PubMed Link] | [ Full text ]
Sun, RC ; Dukhande, VV ; Zhou, Z.; Young, LEA ; Emanuelle, S.; Brainson, CF ; Gentry, MS "Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers." Cell metabolism 30, 5 (2019): 903-916.e7. [PubMed Link] | [ Full text ]
Zhou, Z.; Kinslow, CJ ; Hibshoosh, H.; Guo, H.; Cheng, SK ; He, C.; Gentry, MS ; Sun, RC "Clinical Features, Survival and Prognostic Factors of Glycogen-Rich Clear Cell Carcinoma (GRCC) of the Breast in the U.S. Population." Journal of clinical medicine 8, 2 (2019): [PubMed Link] | [ Full text ]
Deng, P.; Higashi, RM ; Lane, AN ; Bruntz, RC ; Sun, RC ; Raju, MVR ; Nantz, MH ; Qi, Z.; Fan, TW "Correction: Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS." The Analyst 143, 4 (2018): 999. [PubMed Link] | [ Full text ]
Sun, RC ; Fan, TW ; Deng, P.; Higashi, RM ; Lane, AN ; Le, AT ; Scott, TL ; Sun, Q.; Warmoes, MO ; Yang, Y. "Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing." Nature communications 8, 1 (2017): 1646. [PubMed Link] | [ Full text ]
Deng, P.; Higashi, RM ; Lane, AN ; Bruntz, RC ; Sun, RC ; Ramakrishnam Raju, MV ; Nantz, MH ; Qi, Z.; Fan, TW "Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS." The Analyst 143, 1 (2017): 311-322. [PubMed Link] | [ Full text ]
Sun, RC ; Koong, A ; Giaccia, A ; Denko, NC "Measuring the Impact of Microenvironmental Conditions on Mitochondrial Dehydrogenase Activity in Cultured Cells." Advances in experimental medicine and biology 899, (2016): 113-20. [PubMed Link] | [ Full text ]